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Bitter Orange Extract 95% Neohesperidin

A species of multiple uses, The tree ranges in height from less than 3 m to 9 m, is more erect and has a more compact crown than the sweet orange; The evergreen leaves are aromatic, alternate, on broad-winged petioles much longer than those of the sweet orange; The fruit is round, oblate or oblong-oval, rough-surfaced, with a fairly thick, aromatic, bitter peel becoming bright reddish-orange on maturity and having minute, sunken oil glands. There are 10 to 12 segments with bitter walls containing strongly acid pulp and from a few to numerous seeds. The center becomes hollow when the fruit is full-grown.
Current Uses of bitter orange are for heartburn, loss of appetite, nasal congestion, and weight loss. It is also applied to the skin for fungal infections such as ringworm and athlete's foot.
Antioxidant compounds in citrus fruit may have a role to play in protection against neurodegenerative diseases
The flavanones hesperidin, hesperetin, and neohesperidin were shown to protect against the toxicity of hydrogen peroxide (H2O2), as well as protecting against DNA damage, states the study published in the Journal of Agricultural and Food Chemistry. The researchers report that all three flavanones inhibited the decrease in cell loss at all test concentrations, as well as preventing membrane damage, scavenging reactive oxygen species, and increasing the activity of the antioxidant enzyme catalase.
Furthermore, incubation with hesperidin and hesperetin decreased DNA damage in the cells, while also inhibiting the decrease of glutathione peroxidase and glutathione reductase activities.
In summary, hesperidin, hesperetin, and neohesperidin have neuroprotective effects against H2O2-induced cytotoxicity in PC12 by diverse mechanisms, suggesting that these flavanones may be useful in more complete intervention for neural disorder.

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